Abstract: Chronic kidney disease (CKD) is a chronic disease with progressive deterioration or irreversible damage to renal structure and function. Chemokine CCL2 and its receptor CCR2 have been reported to participate in the occurrence and development of CKD in recent studies, and targeting CCL2／CCR2 signaling pathway has gradually become a research hotspot in the treatment of CKD. In this review, we discuss the role and mechanism of CCL2／CCR2 signaling pathway in CKD to further clarify the pathogenesis of CKD and provide new research evidence for immunotherapy targeting CCL2／CCR2.

Key words: chronic kidney disease, chemokines, CCL2, CCR2