Abstract: A 30yearold man was hospitalized for edema and proteinuria followed by progressive abdominal distension and renal dysfunction.His renal biopsy two months ago at the onset of illness revealed a thrombotic microangiopathy lesion.After admission to our hospital,comprehensive examinations were implemented and uncovered multiple lymphnodes enlargement,hepatosplenomegaly,polyserous effusions,elevated vascular endothelial growth factor (VEGF) level.But neither Mprotein nor clonal plasma cells were detectable.Lymph node biopsy confirmed Castleman Disease.Castleman disease variant POEMS syndrome was the final diagnosis.

Key words: Castleman disease variant POEMS syndromeCastleman disease, POEMS syndrome, polyserous effusion