ISSN 1006-298X      CN 32-1425/R

Chinese Journal of Nephrology, Dialysis & Transplantation ›› 2022, Vol. 31 ›› Issue (1): 45-51.DOI: 10.3969/j.issn.1006-298X.2022.01.008

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Effect of metabolic syndrome on delayed graft function and prognosis of patients with allograft renal transplantation

  

  • Online:2022-02-28 Published:2022-02-18

Abstract: Objective:Analyze the relationship between metabolic syndrome (Mets) and delayed graft function (DGF), and prognosis of patients after renal transplantation.
Methodology:A retrospective analysis of the clinical data of 415 patients who underwent allograft renal transplantation at the 900th Hospital of the Joint Service Support Force of the Chinese Peoples Liberation Army from May 2011 to October 2019. The patients were divided into DGF group and nonDGF group relationship among the age of the donor, cause of death, BMI, terminal SCr, gender, age, transplanted kidney volume/body surface area (RV/BSA), cold ischemia time(CIT), warm ischemia time(WIT), hepatitis B, BMI, diabetes, hyperlipidemia, hypertension, Mets and postoperative DGF and its impact on the prognosis of the recipients were analyzed.
Results:Univariate analysis suggested that cause of death, terminal SCr, cold ischemia time, warm ischemia time, gender, diabetes, hyperlipidemia, BMI, and Mets were risk factors for DGF after renal transplantation (P<005); single factor analysis results which had statistical significance were included in multivariate logistic regression analysis, and the results suggested that terminal SCr(OR=4520,95%CI 2585~7904,P<0001), CIT(OR=2530,95%CI 1273~5028,P=0008), WIT (OR=2249,95%CI 1302~3887,P=0004), hyperlipidemia(OR=2165,95%CI 1078~4348,P=0030)and Mets (OR=7393,95%CI 2243~24368,P=0001) were independent risk factors for DGF after renal transplantation; univariate and multivariate Cox regression analysis suggested that terminal SCr(HR=2269,95%CI 1128~4564,P=0022), CIT (HR=2082,95%CI 1007~4308,P=0048), Mets (HR=5744,95%CI 1215~27153,P=0027) were independent risk factors for renal allograft loss; preoperative patients combined Mets with were more likely to be complicated by kidney stones, poor incision healing, and lung infections.
Conclusion:Patients with Mets had a significantly increased risk of DGF and worse prognosis after kidney transplantation.


Key words: metabolic syndrome, allograft renal transplantation, delayed graft function, risk factorsprognosis