Abstract: Ｏｂｊｅｃｔｉｖｅ：To explore the correlation of circulating growth differentiation factor 15 (GDF15) and nutritional status in chronic kidney disease (CKD) patients.
Ｍｅｔｈｏｄｏｌｏｇｙ：The current study included 231 CKD patients without dialysis. All participants were experienced bioelectrical impedance analysis to evaluate nutritional status. Plasma GDF15 concentration was measured by an enzymelinked immunosorbent assay.
Ｒｅｓｕｌｔｓ：In 231 patients,80 were CKD stage 1~2,69 were CKD stage 3 and 82 were CKD stage 4~5. Plasma GDF15 level was lowest in CKD stage 1~2 group and highest in CKD stage 4~5 group. As eGFR decreased,the hemoglobin,serum albumin,body protein and phase angle reduced. Higher GDF15 concentrations were significantly associated with decreased phase angle at 50 Hz and serum albumin. Compared with patients in the lowest quartile,the highest quartile of GDF15 had a 1532fold increased risk of malnutrition after adjusting for confounding factors（OR=1532，95%CI 394~5953，P<0001）.
Ｃｏｎｃｌｕｓｉｏｎ：The proportion of malnutrition patients increased with the progress of kidney disease. GDF15 can be an independent predictor for malnutrition in CKD. 

Key words: chronic kidney disease, growth differentiation factor 15, malnutritionphase angle