Abstract: Ｏｂｊｅｃｔｉｖｅ：To explore plasma and urine levels of complement activation produces in light chain deposition disease (LCDD) and heavy chain deposition disease (HCDD).
Ｍｅｔｈｏｄｏｌｏｇｙ：A total of 42 cases in LCDD group,14 cases in HCDD group and 10 healthy controls were enrolled.We tested the classic pathway (CP) markers of C1q,alternative pathway (AP) markers of  Bb,lectin pathway (LP) markers MBL,and the coproducts of complement pathways of C3a,C5a and sC5b9 in the plasma and urine of the three groups.
Ｒｅｓｕｌｔｓ：The C3[067 (030,100) g/L vs 082 (052,167) g/L,P＜005)] and C1q levels in the HCDD group were significantly lower than those in the LCDD group[2134 (026,4400) μg/ml vs 6306 (632,56666) μg/ml,P＜005].In the urine,the levels of C1q,Bb,C3a,C5a and sC5b9 in the HCDD group were significantly higher than those in the LCDD group.Plasma C1q was negatively correlated with the serum creatinine level of HCDD (r=-0537,P=0048),and sC5b9 was positively correlated with the 24hour urine protein quantification of HCDD (r=0688,P=0007).Urine C1q,Bb,C3a,C5a and sC5b9 were positively correlated with the 24hour urine protein quantification of HCDD.The urine supernatant C3a,C5a and sC5b9 were positively correlated with the 24hour urine protein quantification of LCDD.
Ｃｏｎｃｌｕｓｉｏｎ：HCDD patients had  activation of complement AP and CP.The degree of complement activation was related to the severity of serum creatinine and proteinuria.