Abstract: Longterm alcohol consumption is a wellknown risk factor for tissue damage.The link between high alcohol consumption and kidney damage is still controversial,and the molecular mechanisms by which alcohol may damage kidney are poorly understood.Up to now,the epidemiological studies that attempt to link excessive alcohol consumption with kidney disease have not been concluded,and there is almost no experimental evidence to directly link alcohol consumption with kidney injury.However,studies conducted mainly in other organs and tissues have shown that alcohol may cause renal dysfunction through several possible mechanisms,such as increase in production of reactive oxygen species leading to oxidative stress,which results in excessive free radicals and finally causes tissue damage and increased inflammation.In addition,the effects of excessive alcohol intake on other major organs (liver,heart,intestines and skeletal muscle) synergistically increase the pathological damage to kidney,but its specific mechanism of action still needs to be confirmed by further studies.