Abstract: Ｏｂｊｅｃｔｉｖｅ：To assess the associations between urine kidney injury biomarker in donation after cardiac death (DCD) donor and outcome of kidney recipient.
Ｍｅｔｈｏｄｏｌｏｇｙ：We prospectively enrolled the data of 101 patients who underwent DCD donor kidney transplantation in our center from October 2015 to May 2017. We collected data of donor and recipient,and the postoperative followup period of all patients was half a year.
Ｒｅｓｕｌｔｓ：Among the 101 recipients,9 recipients (89%)  had delayed graft function. The mean serum creatinine six month after surgery was 1180±352 μmol/L. Univariate anova analysis showed that,the influence factors of delayed graft function (DGF) including serum creatinine (P=002),urinary neutrophil gelatinaseassociated lipocalin  (NGAL) (P<0001),urinary kidney injury molecule1 (KIM1) (P<0001),urinary inteleukin18 (IL18) (P<0001) of the donor,body mass index (BMI) (P=0024),and  primary disease of the recipient (P=0025). Multivariate regression analysis of the above factors showed that donor age (P=004) and urinary NGAL (P<0001) were independent risk factors for DGF. Univariate anova analysis showed that renal function at 6 months after surgery was affected by  BMI (P=001),age (<0001),hypertension (P=0001),urine kim1 (P=0008) and urine NGAL (P=0001) of the donor,BMI (P=0012) and gender (P=0015) of the recipient. Multivariate anova analysis of the above factors showed that independent factors affecting renal function at 6 month after surgery including: urinary NGAL (P=0043),BMI (P=0003),and age (P<0001) of the donor.
Ｃｏｎｃｌｕｓｉｏｎ：Urinary NGAL of DCD donor is associated with DGF of recipient,and it is valuable for the assessment of early renal function.

Key words: kidney transplantationdonation after cardiac death, neutrophil gelatinaseassociated lipocalin, kidney injury molecule-1, inteleukin-18