Abstract:

The TAM receptor tyrosine kinase family consist of TYRO3,AXL,and MER. They have common ligands,GAS6 and PROS1.TAM receptors function as both receptor and enzyme,which can bind to ligands,and phosphorylate the tyrosine residues of target protein. TAM recptors play important roles in mediating extracellular signal transduction. Studies have shown that the TAM family are expressed in various tissues,and play biological function in nervous,immune,hematopoietic and urinary systems. This article reviews the research on the TAM family function in the kidney and other system.

Key words: receptor tyrosine kinase, GAS6, PROS1