Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigate the impact of ABOincompatible（ABOi） living donor kidney transplantation and preconditioning regimens on the immune state of recipients.
Ｍｅｔｈｏｄｏｌｏｇｙ：Nine ABOi living donor kidney transplant recipients and eighteen ABO compatible （ABOc） recipients in our center between March 2018 and September 2018 were included in this study. We prospectively collected and compared the count of T cell subgroups (CD3+,CD4+,CD8+ cells),the count of B cells and the level of cytokines (IL2 receptor,IL6,IL8,TNFα),immunoglobulin (IgG,IgA,IgM,IgE,IgG4) and complement (C3,C4 and properdin B) before and after the pretreatment and transplantation.
Ｒｅｓｕｌｔｓ：The count of B cells in peripheral blood at 7 day,14 day and 1 month after transplantation in ABOi recipients was significantly lower compared to ABOc recipients. The levels of IgG,IgA and IgM at 7 day after transplantation in ABOi recipients were lower than those in ABOc recipients. There was no difference in the serum creatinine and eGFR after transplantation between both groups. During the followup period,no patients died and there was no case of graft loss,rejection and infection.
Ｃｏｎｃｌｕｓｉｏｎ：
The count of B cells in peripheral blood in ABOi kidney transplant recipients was significantly lower,and there was a temporary decline in IgG,IgA and IgM.However,ABOi transplantation didn′t impact the change of T cells,cytokines and complements. ABOi kidney transplantation don′t increase the shortterm occurrence of rejection and infection in recipients.