Abstract:

During the past two decades,there has developed an increasing awareness of antibodymediated rejection(ABMR)The original Banff schema for diagnosis of acute and chronic active ABMR in renal allografts was formulated at the 2001 and 2007 Banff Conferences,and required histologic(microvascular inflammation and transplant glomerulopathy),immunohistologic(C4d in peritubular capillaries),and serologic [circulating donorspecific antibodies(DSA)] evidence for a definitive diagnosisThis schema was updated at the 2013 Banff Conference,recognizing C4dnegative ABMR,intimal arteritis as a potential manifestation of ABMR,and revising definitions and thresholds for glomerulitis and transplant glomerulopathyAt the 2017 Banff Conference,new modifications were made,accepting C4d and thoroughly validated molecular classifiers as surrogate markers for DSA

Key words: antibody mediated rejection, Banff classification, molecular diagnostics, renal transplantation