Abstract:

Ｏｂｊｅｃｔｉｖｅ：this study intends to explore the role of functional magnetic resonance imaging combined with histopathological features in predicting the extent of LN tissue damage,by observing the correlation between multimode functional magnetic resonance imaging and renal tissue activity score and the change slope of renal creatinine.
Ｍｅｔｈｏｄｏｌｏｇｙ：32 patients with LN were enrolled. The sequences included intravoxel incoherent motion diffusion imaging (IVIMDWI),diffusion tensor imaging (DTI),bloodoxygenlevel dependent imaging(BOLD) and Magnetic resonance imaging (MRE).The sequence parameters of renal cortical functional imaging were analyzed and recorded Baseline clinicopathological data and followup data for LN patients were analyzed.Acute nephritis tissue activity index (AI); chronic index (CI) is based on renal biopsy histomorphological analysis.
Ｒｅｓｕｌｔｓ：We found that The standADC（1535±133 vs 1769±171，P<005）and FA（0151±003 vs 0181±004,P<005）descended in the AKI subgroup of lupus nephritis. In followup period,FA（0164±0031 vs 0195±0065，P<0001）is much lower in the patients with renal function deterioration,and correlated with the descending slope of serum creatine. The DTIFA had a predictive value for the change of serum(AUC 615%,P<005).We did not found any differences between LN with CKD in BOLD and MRE.
Ｃｏｎｃｌｕｓｉｏｎ：DTIFA and IVIMADC is promising in prediction of renal function.More effort should be paid to monitor renal function prognosis in the future by functional magnetic resonance imaging.

Key words: Lupus nephritis, renal function, magnetic resonance imaging, intravoxel incoherent motion, diffusion tensor imaging