Abstract:

Tacrolimus and cyclosporine are calcineurin inhibitors widely used in organ transplantation and autoimmune diseases,both of them mainly metabolized by cytochrome P450 (CYP450),and the gene polymorphism of CYP3A5 has a significant effect on tacrolimus metabolism.The usage of immunosuppressive agents is a risk factor for fungal infection,and triazole antifungals are widely used as broadspectrum antifungal drugs in clinical practice.The metabolic pathway of each triazole antifungal is different,and the metabolism of voriconazole is greatly affected by the gene polymorphism of CYP2C19.Administration of tacrolimus,cyclosporine and triazole antifungals may results in a drugdrug interaction(DDI).This review summarizes the metabolism and DDI of tacrolimus,cyclosporine and triazole antifungals in order to provide reference for clinical application.

Key words: tacrolimus, cyclosporine, triazole antifungals, gene polymorphism, drug-drug interaction