Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigate the influence of berberine on intestinal bifidobacterium and inflammatory factors in metabolic syndrome patients with renal damage.
Ｍｅｔｈｏｄｏｌｏｇｙ：Twenty metabolic syndrome patients with renal damage were randomly divided into basic treatment group (control group,n=10) and berberine group (treatment group,n=10).Berberine was describe with basic treatment for 8 weeks.At the same time,10 healthy persons who  matched sex and age were selected as normal group.
Ｒｅｓｕｌｔｓ：After 8 weeks of treatment,BMI,SBP,DBP,FBG,2hPBG,FINS,TG,LDLC and UmALb/Ucr was decreased significantly in the treatment group (P<005);SBP,DBP and UmALb/Ucr in control group was also significantly decreased (P<005).There were statistically significance.in BMI,FBG,2hPBG,FINS,TG and LDLC (P<005) between two groups.After 8 weeks of treatment,blood and urine IL6 in change treatment group was decreased significantly,while that of control group did not change significantly (P<005).After 8 weeks of treatment,the number of intestinal bifidobacteria in treatment group was increased significantly,while that of control group did not  significantly (P<005).Spearman correlation analysis showed that the intestinal bifidobacteria were negatively correlated with  blood and urine IL6.
Ｃｏｎｃｌｕｓｉｏｎ：
Berberine can increase the number of intestinal bifidobacterium,and reduce  of serum and urine IL6 levels in patients with metabolic syndrome conbined with renal damage,improve  metabolic disorder of  glucose and lipid,reducing fasting insulin  and body weight.

Key words: metabolic syndrome, intestinal bifidobacteria, renal damageberberine