Abstract:

Ｏｂｊｅｃｔｉｖｅ：To analyze the concentration of urine angiotensinogen (AGT) in patients with chronic kidney disease (CKD),and to explore the significance of urinary AGT excretion in the diagnosis of CKD.
Ｍｅｔｈｏｄｏｌｏｇｙ：Clinical data of CKD and non CKD patients from the CKD resource repository in a crosssectional survey were collected. CKD patients were divided into 3 groups according to estimated glomerular filtration rate (eGFR): CKD 1 group, CKD 2 group and CKD 3 group. Urine AGT was detection by ELISA method.
Ｒｅｓｕｌｔｓ：A total of 95 CKD patients and 413 non CKD controls were enrolled in this study. Urine AGT in CKD group was significantly higher than that in non CKD group (2439±479 vs 1584±2514, P<001), With the decrease of eGFR, urine AGT level increased, it was 2136±345 ng/L, 2514±172 ng/L and 3149±276 ng/L in CKD 1 group,  CKD 2 group and CKD 3 group respectively (F=81103, P<001). Multiple linear regression analysis showed that urine AGT was negatively correlated with eGFR (P<001) and positively correlated with urine albumin/creatinine (P<001) and serum creatinine (P<001).
Ｃｏｎｃｌｕｓｉｏｎ：
Urinary AGT excretion was significantly elevated in CKD patients, and it was negatively correlated with eGFR. Urine AGT may be a useful biomarker of CKD.

Key words: chronic kidney disease, angiotensinogen, renin-angiotensin system