Chinese Journal of Nephrology, Dialysis & Transplantation

ISSN 1006-298X      CN 32-1425/R

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Chinese Journal of Nephrology, Dialysis & Transplantation ›› 2017, Vol. 26 ›› Issue (5): 471-475.DOI: 10.3969/j.issn.1006-298X.2017.05.017

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The cells which produced erythropoietin (EPO) in kidney is called renal EPOproducing cells (REPs). Insufficient production of EPO can cause renal anemia and anemia associated with chronic disease disorders. REPs transformed into scarforming myofibroblasts, resulting in renal fibrosis, chronic kidney disease (CKD) patients the EPOproducing ability of myofibroblasttransformed REPs (MFREPs) is decreased. Recently studies on REPs made great progress and the research is expected to become the treatment of renal anemia and renal interstitial fibrosis new target.

  

  • Online:2017-10-28 Published:2017-10-27

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Abstract:

The cells which produced erythropoietin (EPO) in kidney is called renal EPOproducing cells (REPs). Insufficient production of EPO can cause renal anemia and anemia associated with chronic disease disorders. REPs transformed into scarforming myofibroblasts, resulting in renal fibrosis, chronic kidney disease (CKD) patients the EPOproducing ability of myofibroblasttransformed REPs (MFREPs) is decreased. Recently studies on REPs made great progress and the research is expected to become the treatment of renal anemia and renal interstitial fibrosis new target.

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