Abstract:

Ｏｂｊｅｃｔｉｖｅ：Anemia is a common complication in the maintenance hemodialysis (MHD) patients, and it is difficult to keep the realtime hemoglobin level stable. This study aimed to analyze the risk of cardiocerebrovascular events and death in terms of hemoglobin variability.
Ｍｅｔｈｏｄｏｌｏｇｙ：The hemoglobin concentration of eighty MHD patients were tested monthly, at the end of 9months observation, patients were grouped according to the indicators of hemoglobin variability. The observational end point were death, cardiovascular or cerebrovascular events.
Ｒｅｓｕｌｔｓ：The independent risk factors of the clinical adverse events were the hemoglobin standard deviation, coefficient variation, mean differences between 9 times results, while the hemoglobin concentration was protective factor; the independent risk factors of the cerebrovascular events were the hemoglobin standard deviation and coefficient variation; the independent risk factors of the cardiovascular events was mean differences between 9 times results. Multiple stepwise regression analysis showed that mean differences between 9 times results were an independent risk factor of death, while the hemoglobin concentration was protective factor.
Ｃｏｎｃｌｕｓｉｏｎ：
Hemoglobin variability is common in the anemic patients undergoing MHD. Lower hemoglobin level and higher residual standard deviation (SD) of hemoglobin level are associated with higher risk of clinical adverse events.