Abstract:

Ｏｂｊｅｃｔｉｖｅ：To study the early renal damage caused by obstructive sleep apnea syndrome (OSAS).
Ｍｅｔｈｏｄｏｌｏｇｙ：One hundred eighty OSAS patients and were evaluated by polysomnography during sleep, and 60 healthy individuals were regarded as controls. The levels of serum creatinine (SCr), serum cystatin C (sCys C) and other biochemical data were measured. The levels of urine ACR、β2MG、Cys C and KIM1 were also detected. 30 cases sampled randomly from moderate and severe degree OSAS patients respectively were treated by continuous positive airway pressure (CPAP). The correlation data was detected one month later to known whether there was a change before and after treatment.
Ｒｅｓｕｌｔｓ：There was no difference in the level of BUN、SCr and GFR between OSAS group and control group. The level of sCys C in severe degree group was higher than that in control group, mild and moderate degree group. The level of UACR、uβ2MG、uCys C and uKIM1 in OSAS group was significantly higher than that in control group, and there was significant difference in each OSAS subgroups. The level of UACR、uβ2MG in severe degree OSAS group was higher than that in mild and moderate degree group. The level of apnea hypopnea index (AHI) in OSAS group was positive correlated to uCys C and uKIM1. The level of AHI、the lowest pulse oxygen saturation (LSpO2) at night、sCys C、UACR、uβ2MG、uCys C and uKIM1 were significantly reduced by CPAP treatment.
Ｃｏｎｃｌｕｓｉｏｎ：The early kidney injury caused by OSAS is a main of renal tubular injury. The levels of UACR、uβ2MG、uCys C、uKIM1 and sCys C are significantly increased in patients with kidney  injury, and their changes are earlier than those of conventional renal functions. They may be used as sensitive indicators for monitoring early renal damage in patients with OSAS. Early kidney injury of OSAS can be reversed by CPAP treatment .