Abstract: Fast peritoneal solute transfer rate (PSTR) is a common manifestation of peritoneal dysfunction, which can lead to peritoneal ultrafiltration failure and increase the mortality risk for patients undergoing peritoneal dialysis (PD). For patients with fast PSTR, current guidelines recommend shortening the dwell time of glucose PD solution, selecting a higher concentration of glucose PD solution, or using icodextrin PD solution. PD solutions can be classified based on the type of osmotic agent into crystalloid PD solutions or colloid PD solutions, with glucose PD solution and amino acid PD solution representing the former, and icodextrin PD solution representing the latter. The transmembrane action mechanisms of crystalloid and colloid PD solutions differ, and their combined use is expected to exert a synergistic effect, thereby improving the issue of decreased peritoneal ultrafiltration associated with fast PSTR.

Key words: peritoneal dialysis, peritoneal solute transfer rate, osmotic pressure