Abstract: Ｏｂｊｅｃｔｉｖｅ：To analyze the relationship between bone mineral density (BMD) and body composition in male maintenance hemodialysis (MHD) patients.
Ｍｅｔｈｏｄｏｌｏｇｙ：A netrospective analysis with 83 male patients who were in stable condition on regular dialysis at Zhabei Central Hospital, Jingan District, Shanghai, China, in March 2021. Body fat mass (BFM), body fat percentage (PBF), muscle mass (SLM), defatted body mass (FFM), skeletal muscle mass (SMM), and skeletal muscle mass index (SMI) were determined using a body composition analyzer. Dual-energy X-ray absorptiometry bone densitometry was used to detect proximal radius bone density. Differences in body composition and bone density between osteoporosis and non-osteoporosis groups were analyzed.
Ｒｅｓｕｌｔｓ：83 male MHD patients with age (60.80±13.29) years, dialysis duration (43.14±43.86) years, and 27 (32.5%) with osteoporosis. BMD, SLM, FFM, SMM, SMI, body mass index (BMI), and BFM were lower in the osteoporosis group than in the non-osteoporosis group. Spearman correlation analysis showed that SLM, FFM, SMM, BMI, and SMI were significantly and positively correlated with BMD (r=0.360, P=0.001; r=0.354, P <0.001; r=0.354, P=0.001; r=0.353, P=0.001; r=0.390, P<0.001). The results of multiple linear regression analysis suggested that SMI was an independent factor influencing BMD in male HD patients (β=0.419, P<0.001).
Ｃｏｎｃｌｕｓｉｏｎ：SMI is an independent factor influencing BMD in male HD patients. Improving muscle mass can help to improve BMD and reduce the risk of osteoporosis in male HD patients.

Key words: male, hemodialysis, body composition, bone mineral density