Abstract:

Sepsis  is  defined  as  life⁃threatening  organ  dysfunction  caused  by  a  dysregulated  host  response  to infection.Blood purification therapies have  been proposed  as  adjuvant  therapies  to  modulate  the  dysregulated  inflammatory response. These therapies aim mostly at removing cytokines and endotoxins from the blood. However, so far, they failed to clearly  demonstrate  an  improvement  in  patient  survival  when  evaluated  in  randomized  trials.   Recently,  new  blood purification devices directly targeting  the  primary  determinants  of  sepsis,  the  pathogen  itself  and  the  host  immune  cells, have been developed. New devices may be an effective treatment for sepsis.

Key words: blood purification therapy   , adsorption   , sepsis    pathogen   , immune cell