Abstract: Ｏｂｊｅｃｔｉｖｅ：To investigate the clinical characteristics, pathogenetic features and prognostic factors of patients with renal disease who developed hospitalacquired infections.
Ｍｅｔｈｏｄｏｌｏｇｙ：Patients with renal diseases combined with hospitalacquired infections admitted to the National Center for Clinical Medical Research in Kidney Diseases from December 2011 to December 2021 were retrospectively analyzed for their clinical data, pathological diagnosis and risk factors for poor prognosis.
Ｒｅｓｕｌｔｓ：Among 152 patients with combined nosocomial infections, pulmonary infections (51 cases, 3355％) were the most prevalent. In 84 individuals, 123 pathogenic strains were cultured, and 4065％ of those strains were multidrug resistant bacteria. The most prevalent pathogen was Escherichia coli (1545％), which was followed by staphylococcus aureus (1057％). High neutrophiltolymphocyte ratio (NLR), low CD4+lymphocyte count at the time of admission , and infection with multidrug resistant organisms were independent risk factors for poor prognosis in 17 patients (1118％) with nosocomial infections. In patients with nosocomial infections, the combination of NLR upon admission and CRP at the time of infection had prognostic value for a poor prognosis (AUC=0715, P<0001).
Ｃｏｎｃｌｕｓｉｏｎ：Patients with kidney diseases and hospitalacquired infection presented with high NLR and multidrug resistant bacteria infection should be identified early to reduce the risk of poor outcome.

Key words: nosocomial infection, neutrophil-to-lymphocyte ratio, pathogenic bacteria