Abstract: ＴRenal fibrosis is the main pathological change of chronic kidney disease with various causes. It has been found that histone acetyltransferases (HATs) mediated epigenetic modification was tightly associated with the occurrence and development of renal fibrosis. The p300／CBP family consisting of the highly homologous adenovirus E1Aassociated 300 kDa protein (p300) and cAMP responsive element binding protein (CREB) binding protein (CBP) is one of the major members of the HATs families. This paper reviewed the structure, function, and the role of p300／CBP in renal fibrosis, attempting to provide new targets and ideas for the prevention and treatment of renal fibrosis.

Key words: histone acetyltransferases, p300／CBP, renal fibrosis