Abstract: ＴThe H factor family is a regulatory protein for complement alternative pathway.The pathogenesis and progression of a variety of kidney diseases are related to H factor family,such as atypical hemolytic uremic syndrome,C3 glomerulonephritis,dense deposit disease,IgA nephropathy,lupus nephritis,etc.Genetic studies suggest that H factor family plays an important role in occurrence and development of some kidney diseases.Clinical and functional studies have confirmed that,structure and concentration of factor H family proteins affect the activation of alternative complement pathway.Studies also promote the application of factor H family in disease diagnosis and treatment.This article reviews the influence of factor H family on diseases and introduces the progress of diagnosis and treatment.