Abstract:

Abstract：Chronic kidney disease (CKD) is becoming a worldwide epidemic. Novel targets and treatments for CKD are, therefore, desperately needed to both mitigate the burden of this disease in the general population and reduce the necessity for renal replacement therapy in individual patients. This review highlights new insights into the mechanisms that contribute to CKD, and approaches that might facilitate the development of disease arresting therapies for CKD. Particular focus is given to therapeutic approaches using antifibrotic agents that target the transforming growth factor β superfamily. In addition, we discuss new insights regarding the roles of vascular calcification, the NADPH oxidase family, and NF-kb pathway in the pathogenesis of CKD.

Key words: chronic kidney diseases, therapeutic target, drugs