Abstract:

ABSTRACT Following the kidney injury, the repair can result in functional tissue becoming a patch of cells and disorganized extracellular matrix, or it can recapitulate the original tissue architecture through the process of regeneration. The kidney regeneration has cellular regeneration, which is conserved in all animal species from the ancestral phases of evolution. Another type of regenerative response is nephron neogenesis, which does not occur in adult mammals including human. The converging evidence suggests that a renal progenitor system is present in the adult kidney across different stages of evolution. In this review, we will describe the similarities and differences between the renal progenitor regeneration systems through evolution. Understanding the mechanisms that drive renal progenitor growth and differentiation represent the key step for modulating this potential for therapeutic purposes.

Key words: stem cell, progenitor, mammal, nephron, repair