Abstract:

ABSTRACT: Macrophage infiltration and activation plays an important role in the progression of chronic kidney diseases (CKD). Macrophages comprise a heterogeneous population of cells. Different activation phenotype macrophages play different function. M1 phenotype macrophages promote tissue inflammation and fibrosis, however M2 phenotype macrophages may play anti-fibrotic function and promote tissue repair. The present review provides an in-depth account of the role of activation phenotype macrophages in progression of CKD, and looks forward to using regulation of macrophage function as a tool to treat kidney diseases in the future.

Key words: kidney disease, macrophages