Abstract:

ABSTRACT  Objective: To study plasma 25-hydroxyvitamin D (25(OH)D) levels, cardiac structure and function, and their relationship in patients with maintenance hemodialysis (MHD).  Methodology: Totally one hundred and six MHD patients in our medical center were enrolled in this study. The patients' gender, age, blood pressure, disease history, dialysis history, and medication were investigated. The blood routine, calcium, phosphate, intact parathyroid hormone (iPTH), and 25(OH)D were tested, and doppler echocardiography were also examined for cardiac structure and function.  Results: The serum 25(OH)D in 126 MHD patients was 40.3±19.8nmol/L, male and females' were 42.9±20.2nmol/L and 36.7±18.8nmol/L, respectively. Based on the definition of vitamin D severe deficiency (＜25nmol/L), deficiency (25-50nmol/L), insufficiency (50-75nmol/L), and sufficiency (≥75nmol/L), these patients accounted for 20.63%, 53.18%, 19.84%, and 6.35%, respectively. Left ventricular mass (LVM) was 196±56g, male and females' were 207±59g and 181±50g, respectively (P=0.010). Left ventricular mass index (LVMI) was 119±33g/m2, male and females' were 120±34g/m2 and 118±33g/m2, respectively. The total prevalence of left ventricular hypertrophy (LVH) was 44.4% defined by LVMI ≥125g/m2 in male and ≥110g/m2 in female, the prevalence of female’s was higher than that of male's (58.49% vs 34.25%, P=0.007). The prevalence of cardiac valve calcification (CVC) was 55. 6%, and aortic valve calcification, mitral valve calcification, and both valve calcification was accounted for 44.4%, 27. 8%, and 18.3%, respectively. The left ventricular ejection fraction (LVEF) was 63.1±4.80%, the prevalence of systolic heart failure (LVEF＜50%) was 2.38%. The E/A was 0.83±0.25 in 94 patients, the prevalence of diastolic heart failure (E/A＜1) was 86.5%.  Conclusion: In MHD patients, the deficiency and insufficiency of vitamin D, left ventricular hypertrophy, cardiac valve calcification, and left ventricular diastolic dysfunction were high prevalence.

Key words: 【key words】 , hemodialysis (HD) , 25-hydroxyvitamin D (25(OH)D) , left ventricular hypertrophy （LVH） , cardiac valve calcification （CVC） , heart failure (HF)