Abstract:

Abstract  Objective：To explore the relationship between ambulatory blood pressure and arterial atherosclerosis in the state of uremia, and provide simple and easy reference indicators for the prediction, prevention and prognosis of cardiovascular events in end-stage renal disease (ESRD) patients.Method：This prospective study consecutively collected clinical data of 114 ESRD patients in-hospital cases in the department of nephrology, the first affiliated hospital of Nanjing medical university during August 2012 to December 2012. The data included laboratory data, the ambulatory blood pressure monitoring(ABPM),carotid ultrasound, two-dimensional echocardiography, and the prognosis scores of the death risk.Result：1. A series of ABPM parameters were related with atherosclerosis (P ≤ 0.05). Ambulatory Arterial Stiffness Index (AASI)was the most representative parameter of ambulatory blood pressure, which was also the best indicator for atherosclerosis (logistic regression analysis, P = 0.005). 2. AASI was a comprehensive index of atherosclerosis (P <0.001), left ventricular end diastolic diameter (P = 0.028)and  risk of death(P <0.001). The independent risk factors were age increase (P <0.001), fibrinogen increase (P = 0.009), and serum albumin decline (P = 0.022). Conclusion：AASI, as the representative of ABPM parameters, related well with atherosclerosis, heart remodelling and poor prognosis, whch implied a broader application of ABPM in ESRD patients.

Key words: Keyword：Ambulatory blood pressure, AASI, atherosclerosis, ESRD