Abstract: Ｏｂｊｅｃｔｉｖｅ：To investigate the postoperative renal function changes and renal pathological changes related to metabolic syndrome (MS) in patients with clear cell renal carcinoma.
Ｍｅｔｈｏｄｏｌｏｇｙ：We retrospectively screened clinical information for patients who underwent radical nephrectomy (RN) for clear renal cell carcinoma from December 2012 to January 2017 in Fuzhou Clinical Medical College of Fujian Medical University.
Ｒｅｓｕｌｔｓ：The postoperative eGFR of both groups was significantly lower than that of  preoperative (P<0001) There was no statistically significant in eGFR value at 1 week after operation between the two groups (P>005). During the followup,there was a statistically significant difference in eGFR value at each time point between the two groups (P<005). The number of patients in MS group with CKD3a and above is more than that in nonMS group (P=0048). Renal pathological changes in MS patients included glomerular sclerosis,tubular atrophy and renal interstitial fibrosis.
Ｃｏｎｃｌｕｓｉｏｎ：Renal pathological changes with MS mainly include glomerular sclerosis,renal tubular atrophy and renal interstitial fibrosis  MS affects the recovery of postoperative renal function in RN patients with clear cell renal carcinoma.

Key words: metabolic syndrome, clear cell , renal carcinoma, radical nephrectomy, eGFR, pathology