Abstract:

Farnesoid X receptor (FXR),a bile acid receptor,plays pivotal roles in the regulation of bile acid and lipid metabolism and the maintenance of glucose homeostasis.FXR activation potentially protects against obesity or diabetesrelated kidney damage,as suggested by the latest research advances on the biological function of FXR and its signaling pathways in kidney disease.Here,we reviewed how FXR regulates blood glucose,blood lipids,inflammation,oxidative stress,proteinuria and fibrosis in diabetic nephropathy (DN).We expect to provide novel insight into the role of FXR in the pathogenesis of DN.

Key words: farnesoid X receptor, diabetic nephropathy