Abstract:

Ｏｂｊｅｃｔｉｖｅ：To study the relationship between fibroblast growth factor23 (FGF23), soluble Klotho (sKL) and abdominal aortic calcification in patients with continuous ambulatory peritoneal dialysis (CAPD).
Ｍｅｔｈｏｄｏｌｏｇｙ：One hundred forty seven CAPD patients in our dialysis center were enrolled, whose clinical data were recorded. Serum FGF23 and sKL were measured by ELISA. Xray examination of pelvis was applied to evaluate abdominal aortic calcification. The binary logistic regression was used to analysis the risk factors of calcification. The sensitivity, specificity of FGF23 and sKL in prediction of abdominal aortic calcification was evaluated by the receiveroperating characteristic curve (ROC).
Ｒｅｓｕｌｔｓ：1.The incidence of CAPD patients with abdominal aortic calcification was 374% The abdominal aortic calcification were positively correlated to FGF23, age, dialysis vintage, serum phosphate (P), alkaline phosphatase (ALP), triglyceride (TG), high sensitivity Creactive protein (hsCRP) (P<005),  and were negatively correlated to sKL (P<005). 2. Logistic regression showed that the risk of abdominal aortic calcification above the median FGF23 level (2 77036 pg/ml) was 650 times (OR=650, 95%CI 141-2988) than in and under it. The abdominal aortic calcification risk increased by 7% with every 1 year older (OR=107, 95%CI 103-111). The risk of abdominal aortic calcification above the median serum phosphate level (175 mmol/L) was 349 times (OR=349, 95%CI 109-1114) than in and under it. The risk of abdominal aortic calcification above the median sKL level (29653 pg/ml) was 025 times (OR=025, 95%CI  013-052) than in and under it.3. The ROC curve analysis indicated that, the sensitivity, specificity and area under ROC curve of FGF23 levels in abdominal aortic calcification patients were respectively 910%, 966% and 096 (the cut off point: 2 04514 pg/ml). It was 933%, 948% and 095(the cut off point: 43478 pg/ml) for sKL.
Ｃｏｎｃｌｕｓｉｏｎ：The abdominal aortic calcification in CAPD patients was correlated with the levels of FGF23, sKL, age, dialysis vintage, ALP, phosphate, TG and hsCRP. FGF23 and sKL were all contributed to estimating abdominal aortic calcification. The risk of abdominal aortic calcification was higher in patients with high level of FGF23 and low level of sKL than the others.