Abstract:

The fibrinogen is closely related with blood coagulation, inflammation, atherosclerosis, and cardiovascular disease. In the study field of kidney diseases, the increased fibrinogen in kidney tissues participates in the glomerular lesions and tubulointerstitial fibrosis. Urinary fibrinogen could be used as an early diagnostic marker for acute kidney injury (AKI). In vitro, fibrinogen may induce podocyte through TLRs pathway to secrete some chemokines and cytokines. This paper will summarize the latest research progresses, in order to expand the understanding about pathomechanism of the fibrinogen in nephropathy, and provide theoretical basis for deeper study in kidney diseases.