Abstract:

Abstract：β- catenin plays a dual role in cells, is not only involved in cadherin-mediated intercellular adhesion, but also as the most important information molecules in classical Wnt signaling pathway, regulates cell growth, differentiation and apoptosis. β-catenin can be modified by phosphorylation, ubiquitylation and acetylation. These post-translational modifications influence the stability, translocation and activity of β-catenin as to mediate E-cadherin / β-catenin complex integrity and regulate the Wnt / β-catenin signaling pathway, influencing the expression of β-catenin target genes. And then they affect the progression of renal interstitial fibrosis.

Key words: β-catenin, Post-translational modification, Renal interstitial fibrosis