Abstract:

[Abstract] Microparticles (MPs) from blood cells are nuclear-free plasma membrane vesicles shed from apoptotic or activated cells, which range in diameter is from 0.1μm to 1μm and carries specific parental proteins and components (DNA and RNA) from maternal cytoplasma. Accordingly, the detection of MP membrane proteins can help to tell the source of parental cells and to detect the origin of diseases. It has been reported that the level of circulating MPs is increased during the progression of chronic kidney disease (CKD). Therefore, improved understanding for the mechanism of governing MPs release and their detection methods may be critical to monitor the progression, drug efficacy, and prognosis of CKD. This review summarizes the current knowledge of the molecular mechanisms involved in MP formation and their diverse roles in CKD.

Key words: blood cell microparticle, chronic kidney disease