Abstract:

A 40yearsold woman was characterized by gross hematuria, emaciation and rapidly progressive glomerulonephritis. Her serum MPOANCA was positive and a variety of autoantibodies (ANA, SM, Abeta 2GP1) were also positive, complement C3 decreased and Coombs test was positive. Renal biopsy showed crescentic glomerulonephritis with membranous nephropathy. The diagnosis was type V lupus with ANCA associated vasculitis. After treatment of methylprednisolone pulse therapy and plasma exchange, the serum creatinine returned to normal and MPOANCA and ANA titer decreased.