Abstract:

ABSTRACT Objective: To explore the incidence of cardiovascular calcification and related factors in patients with peritoneal dialysis (PD) . Methodology: From December 2013 to August 2014, one hundred fifty PD patients were enrolled in this study. Laboratory measurements included serum calcium (Ca), phosphorus (P), intact parathyroid hormone (iPTH), and dialysis status was evaluated. Coronary Artery Calcification Score (CACS) was assessed with multi-slice spiral computed tomography (MSCT, Agatston method). Abdominal Aortic Calcification Score (AACS) was assessed with lateral plain radiograph of the abdomen (Kauppila method). Echocardiography was used to detect the cardiac valve calcification (CVC). The related factors of cardiovascular calcification were analyzed by binary logistic regression. Results: Only 58.0%, 46.0% and 23.3% of 150 patients reached the target for serum Ca, P and iPTH defined by Chinese Society of Nephrology (CSN). The total 57.3% patients had calcification. The incidence of CAC, AAC and CVC was found in 40.7%, 32.7% and 27.3% patients respectively. In addition to the individual groups, the incidence of calcification of any part increased with age and dialysis vintage. Using binary logistic regression, age (OR=1.10), dialysis vintage (OR=1.03) were independent risk factors for CAC, but Kt/V as a protect factor (OR=0.27), the independent risk factors for CVC included age (OR=1.07) and serum P(OR=1.94). Conclusion: Although our PD patients had low incidence of cardiovascular calcification (CAC: 40.7%, AAC:32.7%, CVC：27.3%), hyperphosphate and abnormal iPTH were still prominent. Age, dialysis vintage and serum P were traditional risk factors for calcification in patients with PD.