Abstract:

ABSTRACT: Objective: To observe the long-term efficacy and safety of citrate and heparin in locking central venous hemodialysis catheter. Methodology: during June 2011 to December 2012, in a cohort of ninety seven hemodialysis patients with cuffed catheter in right jugular vein were enrolled into this study. According to the way of locking central vein hemodialysis catheter, they were divided into heparin group (5% heparin, n=55) and sodium citrate group (4% sodium citrate, n=42)。The catheter-related infections (CRIs), side effects and catheter patency was accessed and compared between two groups. Results: CRIs were higher significantly in heparin group than that in sodium citrate group (2.49 vs 1.01/ 1000 catheter-day); but patients in sodium citrate group had a lower catheter patency rate than those in heparin group (P<0.05). Conclusion: 4% sodium citrate would be effective in lowing the occurrence of CRIs, but may be increase the risk of catheter thrombosis compared with 5% heparin.

Key words: central vein catheter, hemodialysis, citrate, heparin