Abstract:

ABSTRACT Danger-Associated Molecular Patterns (DAMPs) are the endogenous molecules released from injured or stimulated cells, which can cause innate immune response, and even a subsequent adaptive immunity, thereby playing a vital role in sterile inflammation. Accumulating evidences have shown that DAMPs is involved in the pathogenesis of nephropathies, thus being potential therapeutic targets for the treatment of kidney diseases. This review summarizes recent advances in understanding the roles of DAMPs in the development of kidney diseases.

Key words: kidney disease, DAMPs, PRR