Abstract:

Objective: To determine the clinical experience of using combined modality-simultaneous peritoneal dialysis (PD) and hemodialysis (HD) treatment in patients with end-stage renal disease (ESRD). Methodology: Eleven patients on PD and diagnosed with underdialysis and/or overhydration with declining RRF were recruited in this retrospective study. Parameters of volume control, and uremic solute removal were collected. Results: They were 8 males, 3 females, with a mean age of 50.6±16.5 years old at the start of combined therapy. Mean duration of PD at the start of combined therapy was 3.1±1.2（1.2～4.4）years. Their underlying kidney diseases were 9 casses of chronic glomerulonephritis and 2 cases of diabetic nephropathy. The weekly Kt/V urea increased to 1.96±0.4 from 1.54±0.2L/Week.1.73m2 (p< 0.05). The patients’ hydration status improved significantly with reductions in blood pressure. The hemoglobin level was increased remarkably from 8.6±1.0 to 9.6±1.3g/dl (p < 0.05) even though at the same time the dose of recombinant human erythropoietin decreased significantly. The level of serum albumin was also increased after concomitant HD use. Conclusion: PD and Hemodialysis are not mutually exclusive. They can be used in combination to achieve targeted solute clearances, to improve certain clinical conditions and nutrition status.

Key words: Key Words: Combination Therapy with Hemodialysis and Peritoneal Dialysis, End stage renal diasease, Residual renal function