Abstract:

ABSTRACT   Pre-sensitized patients have a higher risk of rejecting renal allografts. Donor-specific anti-HLA antibodies (DSAs) and memory T cells play a critical role in renal transplant rejection and represent a major obstacle for a successful long-term outcome in kidney transplantation. The development of effective desensitization protocols is a pressing therapeutic challenge for transplant clinic. Since the late 1990s, there has been a quest for therapeutic strategies to allow for successful transplantation in highly sensitized patients. This review discusses desensitization protocols in pre-sensitized renal allograft recipients and their outcomes including acute and chronic antibody-mediated rejection rate, the new agents available, and the future directions in sensitized patients.

Key words: Key words , presensitized , kidney , transplantation  , rejection , desensitization