Abstract:

ABSTRACT  High mobility group protein B-1 (HMGB-1) is an important late inflammatory mediator．HMGB-1 could be actively excreted by inflammatory cells, and may also be passively released by the dying cells into the extracellular milieu, and then mediates the inflammation reaction. Recently, the role of HMGB1 in various kidney diseases is suffered much concern. Results from previous studies have demonstrated that HMGB-1 played a vital role in the pathogenesis and development of lupus nephritis, ANCA-associated vasculitis with renal manifestations, acute kidney injury, interstitial nephritis, renal ischemia-reperfusion injury, and it correlated with many markers of inflammation and malnutrition in CKD and dialysis patients. This review is focused on the recent progresses of HMGB-1 in kidney diseases.

Key words: Key words , HMGB-1 , inflammatory mediator , kidney disease