ISSN 1006-298X      CN 32-1425/R

Chinese Journal of Nephrology, Dialysis & Transplantation ›› 2013, Vol. 22 ›› Issue (3): 254-257.

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β-arrestin  research  advancements  in  AngiotensinⅡ  signal  pathway

  

  • Online:2013-06-28 Published:2013-07-03

Abstract:

Abstract: Arrestin family has recently drawn much attention in signal transduction research, including RAS (renin-angiotensin-systerm)signaling. It has been found that there are two independent signal pathways following the activation of angiotensinⅡreceptor type 1 (AGT1R) by angiotensinⅡ (AngⅡ):G-protein signal pathway and β-arrestin signal pathway. This review article summarizes the role of β-arrestin in Ang Ⅱsignal pathway, particularly focusing on β-arrestin signal pathway. 

Key words: Key Words:&beta, -arrestin;AngiotensinⅡ;AT1R;