Abstract:

ABSTRACT Objective: To investigate the prevalence and the risk factors of essential hypertension (EH) in inpatients with CKD in Urumqi, Xinjiang. Methodology: Nine hundred and eighty-two EH inpatients were enrolled between March 2011 and February 2012 in hypertension department of the First Affiliated Hospital of Xinjiang Medical University in this retrospective study. The  univariate and multivariate logistic regression were performed performed to analyze the risk factors of EH with CKD. Results: (1) In 982 cases of EH inpatients, the prevalence of proteinuria, reduced eGFR and CKD was 20.3%, 5.2% and 23.5%, respectively. The CKD (26.6% vs 20.2%) were more prevalent in male than that in female, there were significant differences in prevalence between them. The reduced eGFR (4.3% vs 6.2%) was more prevalent in female than that in male, but there was no significant difference. The EH with proteinuria (19.5% vs 22.7%), reduced eGFR (4.9% vs 6.2%) and CKD (22.7% vs 26.0%) were more prevalent in Uygur than that in Han, but there were no significant differences. (2)The prevalence of CKD was significant increase for systolic blood pressure for each additional 20mmHg. (3)Logistic regression analysis showed: SBP≥140mmHg (OR=1.503, 95%CI 1.021~2.212), diabetes (OR=1.661, 95%CI 1.174~2.351), hyperuricemia (OR=1.691, 95%CI 1.194~2.395) was independent risk factors of EH with CKD. Conclusion: EH with CKD was associated with systolic blood pressure, diabetes, and hyperuricemia. To control blood pressure, glucoseand and uric can reduce the occurrence and development of CKD.

Key words: Key words：essential hypertension, chronic kidney disease, risk factors