Abstract:

ABSTRACT Objective: To investigate the incidence, clinical manifestation and risk factors of pulmonary fungus infection in hospitalized patients with chronic kidney disease (CKD). Methodology: Twenty five patients, who acquired pulmonary fungus infection with CKD in our centre during from Nov 2009 to Nov 2011, were enrolled this study. Their clinical manifestation and risk factors of pulmonary fungus infection were retrospectively investigated. All patients had pathogen and image examination, and accepted antifungal drugs. Results: 25 cases (2.9%) of pulmonary fungus infection were found among 874 in renal ICU。 They were 13 males and 12 females with the age ranged from 21 to 76 years old. The patients with lupus nephritis and systemic vasculitis were easy to get infection. Among them, 13 cases were infected with Candida albicans, 8 with Aspergillus, 2 with Candida tropicalis, one with Candida glabirate and one with Crypococcus. 19 cases of them (76%) were taken immunosuppressant before infection. The predisposing factors included advanced age, immunosuppressant, anemia, hypoproteinemia, immune deficiency, diabetes and use respirator. Conclusion: The patients who received immunosuppressive drugs may predispose to pulmonary fungus infection, and the most common fungus was Candida albicans. The prognosis will be better if the predisposing factors be controlled and the diagnosis and treatment is in time.

Key words: kidney disease, pulmonary fungus infection, risk factors