Abstract:

ABSTRACT   JAK/STAT pathway is the principal signaling mechanism for a variety of cytokines and growth factors. JAK activation stimulates cell proliferation, differentiation, apoptosis, migration, immune regulation and inflammation. The recent research has verified that JAK/STAT pathway could regulate progression of tubular-interstitial fibrosis through mediating pathological activation and injury of macrophages, myo-fibroblasts and tubular epithelial cells. Further investigation on the mechanisms of signal transduction by JAK/STAT pathway could help us to better understand the inflammation network in renal fibrosis and provide the new targets for intervention treatment.

Key words: Key words   , JAK/STAT pathway   , inflammation     , renal interstitial fibrosis