Abstract:

Aggressive resuscitation therapy is the most basic and most important medical treatment in patients with critically ill. Fluid overload may occur in critically ill as a result of aggressive resuscitation therapies. In such circumstances, persistent fluid overload must be avoided since it does not benefit the patient while it may increase the mortality. When organ failure develops in critically ill patients, fluid overload has been shown to be associated with worse outcomes in multiple disparate studies. It has been shown that diuretics should be only short term as long as it is effective，while other multiple randomized controlled trials have not shown benefit in the use of diuretics, either to prevent AKI or to treat established AKI. If fluid overload and the patient does not respond to diuretics, early initiation of continuous renal replacement therapies may be preferable.