Abstract:

ABSTRACT  Objective: This study aimed to compare glomerular filtration rate (GFR) changes in the elderly and non-elderly, male and female living kidney donors before and after transplantation, and to further evaluate the compensation of GFR in each group. Methodology: Eighty four living kidney donors were divided into the male group (n=54) and female group (n=30), or elderly group (age over 50，n=25) and non-elderly group (n=59) .The total GFR was calculated with the MDRD formula, Meanwhile, bilateral GFR was determined by 99m TC-DTPA radionuclide assay, and then the preoperative estimated GFR (eGFR) of donor kidneys was calculated. Within half year following after operation, the maximum eGFR of graft kidneys was calculated and compared each group after operation. Results: The general eGFR of donor kidneys preoperatively was 54.8±13.5ml/(min×1.73m2), while 76.7±32.27ml/(min×1.73m2) postoperatively. The compensation rate of eGFR was 47.16%. In elderly group, the compensation rate of eGFR was 45.9±51.8%, while 44.9±69.8 % in non-elderly group. The compensation rate of eGFR was 41.9±40.4% in male group while 56.6±96.9% in female group. The compensation rate of eGFR was negatively correlated with preoperative eGFR and the age of recipients. Although the pre- and post-operative eGFR of living donor kidneys in the elderly group was both lower than non-elderly group, the eGFR in the elderly group and female group was well-compensated. Conclusion: After transplantation, the eGFR compensation rate of living donor kidneys was significantly elevated, but it was significant individuals. The pre- and post-operative parameters between female and male graft were similar, and thus preoperative evaluation on the compensation of living donor kidneys should carefully consider the basic eGFR and the needs of recipients. 

Key words: living donor kidney transplantation  , marginal donor  , graft kidney function  , glomerular filtration rate  , compensation rate