Abstract:

The key factor of acute tubule necrosis and the failure of renal transplant is renal ischemia reperfusion injury (RIRI), how to relieve or prevent it is always the key issues of protection of renal injury. The pathological mechanism of RIRI is very complicated, the data of current research demonstrate that some vaso-active substances，such as ET-1, NO, the renin–angiotensin system（RAS）of angiotensin II or Ang-(1–7) play an important role in RIRI, and take part in the occurrence and development of renal injury.