Abstract:

Objective: To analyze the current situation of peritoneal dialysis in our country and the factors influencing the long-term prognosis by review of single peritoneal dialysis center registration data system.  Methodology:Patients on maintenance PD were retrospectively studied from January 2002 to December 2010. The Kaplan–Meier method for measuring patient survival rate and technique survival rate were applied. We also analyzed the risk factors and calculated their hazard ratio (HR) for patient mortality and PD technique failure using multivariate regression of the Cox proportional hazards method.   Results：A total of 681 patients were recruited. Among them, 398 (58.5%) were males, and the mean age at the start of PD was 45.7±16.4 years old, Chronic glomerulonephritis（CGN）was the main cause of end stage renal disease（ESRD）, and followed by diabetes mellitus (11.8%). Mean PD duration was 13.9±16.4 months. There were 604 cases (88.7%) receiving day ambulatory peritoneal dialysis (DAPD), while 77 (11.3%) got continuous ambulatory peritoneal dialysis (CAPD). The 1, 3, 5 and 8 years of technical survival rates were 87.0%, 74.4%, 61.8% and 53.0%, respectively. While the 1, 3, 5 and 8 years of patient survival rates were 94.8%, 78.9%, 70.6% and 48.5%, respectively.Excluded patients giving up treatment due to economic factors，the causes of quit PD were cardiovascular diseases (23%~41%), dialysis inadequacy (25%~43%)，peritonitis (10%~16.7%).catheters complications(6.7%-10.3%) and pleural effusion (0-6.7%).The main causes of death were cardiovascular events (23%~41%), cerebrovascular events (12.5%~20%) and infection (6.3%~15.4%).The predictors of patient drop-out in our study were anemia [relative risk (RR) 0.53, p < 0.01], protein energy malnutrition (RR 0.77, p < 0.05),low serum albumin level (RR 9.49, p < 0.01) upon starting PD.  Conclusion：The patients with PD in our center had a good technical survival rate. The main factor influencing the prognosis was cardiovascular diseases and dialysis inadequacy.