Abstract: A 48-year-old male patient was admitted to the hospital for proteinuria with more than 3 years. Clinical manifestations were moderate proteinuria,no microscopic hematuria or renal dysfunction Renal biopsy showed renal amyloidosis with positive staining of κ light chain and IgG1. The proportion of bone marrow plasma cells was normal,a small number of monoclonal plasma cells was detected in immunophenotyping,the absolute value and ratio of serum free light chain were normal,urinary free κ light chain increased,M protein was not detected in serum and urine,and there was no evidence of involvement of heart,gastrointestinal tract or skin. It was diagnosed as heavy and light chain renal amyloidosis. The patients were treated with bortezomib-based regimen. 

Key words: renal amyloidosis, immunoglobulin heavy and light chain amyloidosis, renal pathology